機電工程學系

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系所沿革

為迎合產業機電整合人才之需求,本校於民國 91年成立機電科技研究所,招收碩士班學生;隨後並於民國93年設立大學部,系所整合為「機電科技學系」,更於101學年度起招收博士班學生。103學年度本系更名為「機電工程學系」,本系所之發展方向與目標,係配合國家政策、產業需求與技術發展趨勢而制定。本系規劃專業領域包含「精密機械」及「光機電整合」 為兩大核心領域, 使學生不但學有專精,並具跨領域的知識,期能強化學生之應變能力,以適應多元變化的明日社會。

教學目標主要希望教導學生機電工程相關之基本原理與實務應用的專業知能,並訓練學生如何運用工具進行設計、執行、實作與驗證各項實驗,以培養解決機電工程上各種問題所需要的獨立思考與創新能力。

基於建立系統性的機電工程整合教學與研究目標,本系學士班及研究所之教育目標如下:

一、學士班

1.培育具備理論與實作能力之機電工程人才。

2.培育符合產業需求或教育專業之機電工程人才。

3.培育具備人文素養、專業倫理及終身學習能力之機電工程人才。

二、研究所

1.培育具備機電工程整合實務能力之專業工程師或研發人才。

2.培育機電工程相關研究創新與產業應用之專業工程師或研發人才。

3.培育具備人文素養、專業倫理及終身學習能力之專業工程師或研發人才。

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    用於細胞配對與融合之微流體技術發展
    (2023) 楊景奕; Yang, Jing-Yi
    現今融合細胞,已被廣泛應用於生物醫學相關研究,例如誘導形成幹細胞、癌症免疫療法、生產單株抗體、基因圖譜及組織再生等。在融合過程中,最關鍵的步驟,就是確保細胞配對時能緊密接觸,以提高融合效率。在本論文中,我們提出了一種微流體細胞配對融合晶片,該晶片能透過流體動力學(Hydrodynamics)與微結構抓取與配對細胞,研究中利用鞘流(Sheath flow)與斯托克陷阱(Stokes trap)的方式,進行細胞集中與配對,在鞘流與中心流流速比4:1的情況下,能將細胞集中於20 μm以內。研究中所使用之細胞為NIH-3T3,在細胞密度為2×105 cells/ml時,平均配對時間約為20秒。該晶片能透過流場對細胞施加正向應力,使細胞被擠壓,由原本的圓形擠壓成橢圓形,藉以增加配對時細胞之間的接觸面積,在接觸面積增加的情況下,應可增加細胞融合之效果,並應用於後續細胞融合之研究。
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    Three dimensional electrode array for cell lysis via electroporation
    (Elsevier, 2006-10-15) Lu, Kuan-Ying; Wo, Andrew M.; Lo, Ying-Jie; Chen, Ken-Chao; Lin, Cheng-Ming; Yang, Chii-Rong
    Microfabricated devices for cell lysis have demonstrated many advantages over conventional approaches. Among various design of microdevices that employ electroporation for cytolysis, most utilize Ag/AgCl wires or 2D planar electrodes. Although, simple in fabrication the electric field generated by 2D electrodes decays exponentially, resulting in rather non-uniform forcing on the cell membrane. This paper investigates the effect of electric field generated by 3D cylindrical electrodes to perform cell lysis via electroporation in a microfluidic platform, and compared with that by 2D design. Computational results of the electric field for both 2D and 3D electrode geometries showed that the 3D configuration demonstrated a significantly higher effective volume ratio—volume which electric field is sufficient for cell lysis to that of net throughflow volume. Hence, the efficacy of performing cell lysis is substantially greater for cells passing through 3D than 2D electrodes. Experimentally, simultaneous multi-pores were observed on leukocytes lysed with 3D electrodes, which is indicative of enhanced uniformity of the electric field generated by 3D design. Additionally, a single row of 3D electrode demonstrated a substantially higher lysing percentage (30%) than that of 2D (8%) under that same flow condition. This work should aid in the design of electrodes in performing cell lysis via electroporation.